16 August 2019
Zebrafish in Biomedicine and Toxicology
Zebrafish are being used increasingly as animal models in neuro-behavioural and neuro-endocrine research. Reasons for this are the low costs, easy maintenance and a well-defined genome, among others. Given this, zebrafish now replace mice in many paradigms. While this may be valid from one perspective, zebrafish are clearly different from mammals: they are ectothermic rather than endothermic, their nervous system is organised differently, they have a duplicated genome and their behaviour is tailored to an aquatic environment rather than a terrestrial environment. Therefore, it is relevant and timely to address questions on the ins and outs of gene, brain and behaviour research in zebrafish.
Which topics will be discussed?
Crucial to the success of using zebrafish as research models is understanding the unique properties of zebrafish. Therefore the following topics will be addressed during the course: the phylogenetic position of zebrafish; duplicated genome of zebrafish; neuro-anatomy including the nervous system's remarkable plasticity; social (shoaling and interaction) and non-social (anxiety, fear, reward-related) behaviour of zebrafish; neuro-endocrinology (related to stress and metabolism); development from the larval to the adult stage; the 'ecology' of zebrafish ('the wild and the lab'). State-of- the-art techniques will be discussed and demonstrated to unravel and understand gene, brain and behaviour relationships in zebrafish.
How do we achieve an optimal learning environment?
We offer stimulating lectures: interactive and aimed at generating discussions. During the course you will take part in practicals with state-of-the-art techniques and small discussion parties to optimise interaction between lecturers and attendants and among attendants.
Prof dr. Gerrit Flik
Head Department Animal Physiology
This course is designed for master's students and researchers who are currently working or are planning to start working with Zebrafish in the field of gene, brain and behavior.
After this course you are able to:
Address pros and cons of using zebrafish as models in brain and behaviour research
Understand zebrafish brain and behavior
Understand zebrafish genetics
Understand zebrafish neuro-endocrinology
EUR 600: Normal fee
€ 540 early bird discount – deadline 1 March 2019 (10%)
€ 510 partner + RU discount (15%)
€ 450 early bird + partner + RU discount (25%)