Cardiovascular Phenotyping of Human-Disease Relevant Animal Models

The course includes the introduction to major cardiovascular parameters essential for body homeostasis. It will give an introduction to basic molecular and biophysical principles behind the changes of these parameters in major pathological conditions, i.e., hypertension, heart failure, stroke, as well as the potential background for co-morbidity with metabolic (i.e., diabetes, obesity) and neurological (i.e., migraine, stress, Alzheimer disease) pathologies. The hemodynamic background of cardiovascular pathologies and available pharmacological tools will be discussed with clinical experts, followed by presentation of state-of-art animal models in the light of their translational values. The key aspects of comparative physiology that are relevant for our understanding of human pathology will be given in accordance to August Krogh principle that “For a large number of problems there will be some animal of choice, or a few such animals, on which it can be most conveniently studied.” Researchers and experts from the major providers of technical solutions for assessment of cardiovascular function will introduce the approaches (i.e., radiotelemetry, echocardiography, Langendorff preparation, catheterization, ex vivo and in vivo imaging of peripheral and cerebral circulation) and the students will have a possibility for hands-on experience with many of these techniques during practical exercises using porcine and rodent experimental models.

Course leader

Vladimir Matchkov, Michael Pedersen and Tina Myhre Pedersen

Target group

Master's level

Fee info

EUR 380: EU/EEA citizens
EUR 1313: NON-EU/EEA citizens

Scholarships

No scholarships available

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