Target Oriented Synthesis TOS

The course focuses on how to design efficient synthetic routes to organic target molecules with special focus on bioactive compounds (natural products and pharmaceuticals). The course will cover the following main topics: (1) Principles of synthesis design, retrosynthesis and target molecule analysis, (2) Canonical synthetic strategies (transform-based, structure-goal, topological, stereochemical, functional-group based, non-canonical strategies), (3) Divergent and convergent strategies, (4) Symmetry and hidden symmetry, (5) Analysis and comparison of synthetic routes, (6) Implementation of a strategy to design a practical synthesis, (7) Industrial considerations for target oriented synthesis, (8) AI tools in synthesis design.

Course leader

Assistant Professor Juha Siitonen (Aalto University), Dr. Toni Metsänen (Orion Pharma)
Course coordinator(s): Doctoral Researcher Roope Suvinen (JYU)

Target group

Prerequisites for the course: B.Sc. or equivalent in chemistry.

Course aim

Learning outcomes: After the course a student will be able to design, compare and evaluate alternative synthetic routes to target molecules, use chemical databases to help with the synthesis design process, and be able to collaboratively design syntheses. The student will also be able to recognize main challenges in synthesizing target molecules in the industrial field.

Fee info

EUR 0: Participation in the Summer School courses is free of charge, but students are responsible for covering their own meals, accommodation and travel costs as well as possible visa costs.

Scholarships

Jyväskylä Summer School is not able to grant Summer School students financial support.