Amsterdam, Netherlands
Pre-University Honours Programme: Sustainable Thinking
When:
15 July - 25 July 2025
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Social Sciences
When:
09 September - 13 September 2018
School:
Bicocca Summer and Winter School
Institution:
University of Milano-Bicocca
City:
Milan
Country:
Italy
Language:
English
Credits:
10.0 EC
Fee:
1400 EUR
Uses for biomarkers in drug development and clinical care
Kinds of validation (Analytical, Clinical, Medical utility)
Analytical validation (Single analyte, Sequencing panels, Gene expression signatures)
Introduction to case studies of prognostic single analyte biomarkers and biomarker scores
Statistical methods for development of prognostic scores (Discriminant analysis, Shrunken centroids, Nearest neighbour methods, Support vector machines, Penalized logistic regression, Boosting, Random forests, Penalized proportional hazards model)
Retrospective study designs (Prospective-retrospective design with archived specimens; Efficient retrospective sampling (e.g., case-control, weighted); Sample size/power; Optimally splitting dataset)
Prospective designs (Considerations to establish medical utility; Trial examples: TAILORx, MINDACT, RxPONDER (also some predictive aspects), Sample size/power)
Statistical methods for development of predictive scores/classifiers (Score development methods)
Statistical methods for evaluation of predictive scores (Performance measures; Cross-validation for evaluation of predictive performance; Considerations in use of archived specimens; Special case sampling approaches in retrospective study designs)
Hands on workshop on methods for development and evaluation of predictive biomarker classifiers
Evaluation of intermediate endpoint biomarkers (Surrogate endpoints; Patient management biomarkers; Imaging biomarkers; Liquid biopsy based biomarkers)
Biomarker driven clinical trial designs (Basket design, Enrichment design, Umbrella design, Stratified all-comers design, Strategy design, Adaptive signature design, Adaptive threshold design, Adaptive enrichment designs)
Prof. Maria Grazia Valsecchi
Students and Professionals with knowledge of R programming; some knowledge of statistical methods for clinical trials.
Statistic Alps is a residential training course on advanced statistical issues of interest in clinical research. It is traditionally heldin Ponte di Legno, a place in the Alps with beautiful surroundings. The course has reached the 7th edition and this year will be in a winter format. The focus of this edition will be on biomarkers and classifiers for diagnostic and therapeutic research. Biomarkers are becoming increasingly important for streamlining drug discovery and development. They are widely used as a tool for disease diagnosis and for personalized medicine, and they are also used as surrogate endpoints in clinical research. This course is designed to give a comprehensive introduction to clinical research on biomarkers and multivariate classifiers, addressing the entire spectrum from discovery to evaluation.The goals of the course are:
- to understand how to conduct translational research on biomarkers and classifiers
- to be able to analyze data on biomarkers and classifiers and to interpret results.
The methods covered in the course have applications in diagnostic and therapeutic research. The course will consist of lectures and tutorials
When:
09 September - 13 September 2018
School:
Bicocca Summer and Winter School
Institution:
University of Milano-Bicocca
Language:
English
Credits:
10.0 EC
Fee:
1400 EUR, Covers all teaching materials, bus transfer, hotel accomodation and meals from the dinner of the 9th September to the breakfast of the 14th of September IBS/SISMEC member 1300 €
Fee:
1100 EUR, PhD student - Covers all teaching materials, bus transfer, hotel accomodation and meals from the dinner of the 9th September to the breakfast of the 14th of September
Amsterdam, Netherlands
When:
15 July - 25 July 2025
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Amsterdam, Netherlands
When:
20 January - 31 October 2024
Credits:
4 EC
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Zurich, Switzerland
When:
19 January - 24 January 2025
Credits:
2.0 EC
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